Effect of probiotics on oxidative stress and inflammatory status in diabetic nephropathy: A systematic review and meta-analysis of clinical trials. Issue 1 (January 2021)

• Record Type: Journal Article
• Authors: Bohlouli, Jalal; Namjoo, Iman; Borzoo-Isfahani, Mohammad; Hojjati Kermani, Mohammad Ali; Balouch Zehi, Zakiyeh; Moravejolahkami, Amir Reza
• Is Part Of: Heliyon. Volume 7:Issue 1(2021)
• Publication Date: 2021-01
• Subjects: Probiotics -- Oxidative stress -- C-reactive protein -- Diabetic nephropathies -- Meta-analysis; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2021.e05925
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: This systematic review and meta-analysis was performed to evaluate the effect of probiotics on serum high sensitivity-C reactive protein (hs-CRP) and oxidative stress biomarkers among patients with Diabetic Nephropathy (DN). Electronic databases were searched through May 10, 2020. Seven trials that included 340 patients were identified for analysis. Meta-analysis indicated that probiotics significantly reduced hs-CRP (WMD = -1.53 mg/L; 95% CI = -2.38, -0.69; P < 0.001) and Malondialdehyde (MDA) (WMD = -0.62 ɥmol/L; 95% CI = -1.18, -0.06; P = 0.030) levels in DN patients, whereas they increased Glutathione (GSH) (WMD = 73.84 ɥmol/L; 95% CI = 24.3, 123.29; P = 0.003) and Total Antioxidant Capacity (TAC) (WMD = 26.54 mmol/L; 95% CI = 6.23, 46.85; P = 0.010). Therefore, probiotics may improve hs-CRP and oxidative stress biomarkers in DN population. Abstract : Probiotics; Oxidative Stress; C-Reactive Protein; Diabetic Nephropathies; Meta-Analysis