Self-emulsifying drug–delivery systems modulate P-glycoprotein activity: role of excipients and formulation aspects. (3rd August 2018)

• Record Type: Journal Article
• Authors: AboulFotouh, Khaled; Allam, Ayat A; El-Badry, Mahmoud; El-Sayed, Ahmed M
• Is Part Of: Nanomedicine. Volume 13:Number 14(2018)
• Publication Date: 2018-08-03
• Subjects: cancer -- effective concentration range -- multidrug resistance (MDR); Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2017-0354
• Languages: English
• ISSNs: 1743-5889

Abstract

Self-emulsifying drug–delivery systems (SEDDS) have been widely employed to ameliorate the oral bioavailability of P-glycoprotein (P-gp) substrate drugs and to overcome multidrug resistance in cancer cells. However, the role of formulation aspects in the reduced P-gp activity is not fully understood. In this review, we first explore the role of various SEDDS excipients in the reduced P-gp activity with the main emphasis on the effective excipient concentration range for excipient-mediated modulation of P-gp activity and then we discuss the synergistic effect of various formulation aspects on the excipient-mediated modulation of P-gp activity. This review provides an approach to develop a rationally designed SEDDS to overcome P-gp-mediated drug efflux.