Codeine-induced acute generalized exanthematous pustulosis without IL36RN mutations. (19th June 2018)

• Record Type: Journal Article
• Authors: Chadli, Zohra; Ladhari, Chayma; Kerkeni, Emna; Djobbi, Amira; Fredj, Nadia B; Chaabane, Amel; Boughattas, Naceur A; Aouam, Karim
• Is Part Of: Pharmacogenomics. Volume 19:Number 11(2018)
• Page Start: 889
• Page End: 893
• Publication Date: 2018-06-19
• Subjects: AGEP -- codeine -- genetics -- IL36RN mutations -- psoriasis; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs-2017-0200
• Languages: English
• ISSNs: 1462-2416

Abstract

Recent studies have suggested an association between mutations in the IL-36RN gene and the onset of pustular generalized. In the literature, only one case of acute generalized exanthematous pustulosis (AGEP) induced by codeine in a patient with IL36RN mutation has been reported. Herein, we reported an unusual case of AGEP caused by codeine in a patient with a history of psoriasis and confirmed by an oral provocation test. In this case, we have shown that the IL36RN gene mutation is not a constant condition in drug-induced AGEP. Clinicians should be aware of this side effect of codeine especially, in patients with a history of psoriasis. More studies are needed to clarify the association between drug-induced AGEP and IL36RN gene mutations.