Hypoxia and tumor angiogenesis in the era of hepatocellular carcinoma transarterial loco-regional treatments. (1st May 2018)

• Record Type: Journal Article
• Authors: Petrillo, Mario; Patella, Francesca; Pesapane, Filippo; Suter, Matteo B; Ierardi, Anna M; Angileri, Salvatore A; Floridi, Chiara; de Filippo, Massimo; Carrafiello, Gianpaolo
• Is Part Of: Future oncology. Volume 14:Number 28(2018)
• Page Start: 2957
• Page End: 2967
• Publication Date: 2018-05-01
• Subjects: embolotherapy -- HCC -- hypoxia -- individualized treatment -- neoangiogenesis -- sorafenib -- TACE -- TAE -- TARE -- VEGF; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2017-0739
• Languages: English
• ISSNs: 1479-6694

Abstract

This review focuses upon interactions and potential therapeutic targets in the 'vicious cycle' between hypoxia and neoangiogenesis following treatment of hepatocellular carcinoma with transarterial loco-regional therapies. Biomarkers correlated with angiogenesis have been studied by many authors as prognostic determinants following transarterial intrahepatic therapy. According to these results future therapies directed toward specific factors related to angiogenesis could play a significant role in preventing local tumor recurrence and remote metastasis.