Gut microbiota metabolites in autistic children: An epigenetic perspective. Issue 1 (January 2021)

• Record Type: Journal Article
• Authors: Sabit, Hussein; Tombuloglu, Huseyin; Rehman, Suriya; Almandil, Noor B.; Cevik, Emre; Abdel-Ghany, Shaimaa; Rashwan, Sanaa; Abasiyanik, Mustafa Fatih; Yee Waye, Mary Miu
• Is Part Of: Heliyon. Volume 7:Issue 1(2021)
• Publication Date: 2021-01
• Subjects: ASD -- Autism -- Gut -- Microbiota -- Metabolites -- Epigenetics; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2021.e06105
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: Gut microbiota has become an issue of great importance recently due to its major role in autism spectrum disorder (ASD). Over the past three decades, there has been a sustained research activity focused to explain the actual mechanism by which gut microbiota triggers/develops autism. Several genetic and epigenetic factors are involved in this disorder, with epigenetics being the most active area of research. Although the constant investigation and advancements, epigenetic implications in ASD still need a deeper functional/causal analysis. In this review, we describe the major gut microbiota metabolites and how they induce epigenetic changes in ASD along with interactions through the gut-brain axis. Abstract : ASD; autism; gut; microbiota; metabolites; epigenetics.