High-sensitivity troponin T is a prognostic marker of hemodynamic instability in patients undergoing valve surgery. (6th December 2018)

• Record Type: Journal Article
• Authors: Duchnowski, Piotr; Hryniewiecki, Tomasz; Koźma, Małgorzata; Mariusz, Kuśmierczyk; Piotr, Szymański
• Is Part Of: Biomarkers in medicine. Volume 12:Number 12(2018)
• Page Start: 1303
• Page End: 1309
• Publication Date: 2018-12-06
• Subjects: ECMO -- hemodynamic instability -- high-sensitivity troponin T -- IABP -- valve surgery; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm-2018-0186
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: The usefulness of high-sensitivity troponin T (hs-TnT) as a predictor of perioperative hemodynamic instability is currently unknown.Methods: A prospective study was conducted on a group of 708 consecutive patients with significant valvular heart disease that underwent elective valve surgery. The primary end point was postoperative hemodynamic instability. The secondary end point was death from all causes in patients with perioperative hemodynamic instability.Results: The postoperative hemodynamic instability occurred in 131 patients. At multivariate analysis hs-TnT measured immediately after surgery and New York Heart Association classes remained independent predictors of the primary end point. Age and hs-TnT measured immediately after surgery were associated with an increased risk of death.Conclusion: Elevated postoperative hs-TnT was associated with a higher risk of postoperative hemodynamic instability and death.