The lipid peroxidation in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy. (6th December 2018)

• Record Type: Journal Article
• Authors: Woźniak, Paweł; Kontek, Bogdan; Różański, Waldemar; Olas, Beata
• Is Part Of: Future medicinal chemistry. Volume 10:Number 23(2018)
• Page Start: 2685
• Page End: 2693
• Publication Date: 2018-12-06
• Subjects: lipid peroxidation -- nephrolithiasis -- oxidative stress -- uric acid; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.4155/fmc-2018-0149
• Languages: English
• ISSNs: 1756-8919

Abstract

Aim: To evaluate the level of lipid peroxidation in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy (ESWL).Materials & methods: Isoprostane concentration (8-isoPGF2α ) was measured in urine, and thiobarbituric acid reactive substance production in serum and erythrocytes. In addition, the concentrations of selected compounds (uric acid, glucose and creatinine) were measured in serum.Results: The patients (before and after ESWL) demonstrated significantly higher levels of two different biomarkers of lipid peroxidation compared with the control group. A correlation was identified between increased amounts of uric acid and biomarkers of lipid peroxidation in patients with nephrolithiasis, both before and after ESWL.Conclusion: Uric acid may be associated with lipid peroxidation in patients with nephrolithiasis.