The importance of evaluating the chemical structures and strategies to avoid pitfalls in quantitative bioanalysis. (26th November 2018)

• Record Type: Journal Article
• Authors: Licea-Perez, Hermes; Evans, Christopher A; Summerfield, Scott G
• Is Part Of: Bioanalysis. Volume 11:Number 2(2019)
• Page Start: 85
• Page End: 101
• Publication Date: 2018-11-26
• Subjects: bioanalysis -- chemical derivatization -- chemical structure -- glucuronide metabolites -- lactones -- mass spectrometry -- N-oxide metabolites -- prodrugs -- stabilization of drugs; Drugs -- Analysis -- Periodicals; 615.19005
• DOI: 10.4155/bio-2018-0211
• Languages: English
• ISSNs: 1757-6180

Abstract

Quantitative bioanalytical data are crucial in pharmaceutical research and development, allowing project teams to make informed scientific decisions on the progression of candidate molecules to medicines. Many challenges are often encountered during the bioanalysis of drugs in biological matrices which require resolution in a timely manner. In this publication, guidance is provided to bioanalytical scientists on how to identify potential problems before they become an obstacle for the drug development and to share our experiences dealing some of most common problems encountered in the bioanalytical laboratory. Relevant topics in bioanalysis such as stabilization approaches for glucuronides (Acyl and N-); prodrugs (phosphate and esters), amides, amines, N-oxides; bioanalysis of light sensitive molecules, halogenated drugs and lactones are discussed in this publication.