Comparison of glucose variability in patients with type 2 diabetes administrated glargine with needle-free jet injector and conventional insulin pen. (3rd May 2020)

• Record Type: Journal Article
• Authors: Sun, Yixuan; Wang, Jian; Li, Huiqin; Sun, Xiaojuan; Su, Xiaofei; Ma, Jianhua
• Is Part Of: Expert opinion on drug delivery. Volume 17:Number 5(2020)
• Page Start: 713
• Page End: 717
• Publication Date: 2020-05-03
• Subjects: Flash glucose monitoring -- Gla-100 -- glycemic variation -- needle-free jet injection -- type 2 diabetes; Drug delivery devices -- Periodicals; Drug delivery systems -- Periodicals; 615.605
• DOI: 10.1080/17425247.2020.1738381
• Languages: English
• ISSNs: 1742-5247

Abstract

ABSTRACT: Background: The effects of insulin delivered by needle-free jet injector on glycemic variations (GV) in patients with type 2 diabetes (T2D) which remains largely unknown. Research design and methods: We aimed to compare the glucose variability in Chinese T2D patients administrated glargine 100 U/mL (Gla-100) with a needle-free jet injector and conventional insulin pen. This was a self-comparative, observational study of 26 patients who were subjected to a flash glucose monitoring system (FGM) for 14 consecutive days. During the study period, all subjects received Gla-100 daily before breakfast using a conventional insulin pen, with the exception of day 3 and day 7, when insulin was delivered by needle-free jet injection. We analyzed FGM data of day 3, day 5, day 7, and day 9 at the endpoint. Results: There were no differences in the glycemic variability between the jet injector group and the conventional pen group. However, patients with needle-free jet injection had a lower 24 hr mean glucose (MG) and lower incremental area under the curve (AUC) of 1 hr, 12 hr, and 24 hr, compared to the conventional pen group (p = 0.001). Conclusions: Gla-100 delivered by needle-free jet injection potentially lowered MG in patients with T2D in the Chinese population.