Heparin-binding epidermal growth factor (EGF)-like growth factor in pediatric patients with type 1 diabetes mellitus. (3rd March 2020)

• Record Type: Journal Article
• Authors: Kacarevic, Dragana; Bogavac-Stanojevic, Natasa; Spasojevic-Kalimanovska, Vesna; Bojanin, Dragana; Milenkovic, Tatjana; Stefanovic, Aleksandra; Mihajlovic, Marija; Vujcic, Sanja; Vukovic, Rade; Zeljkovic, Aleksandra; Kotur-Stevuljevic, Jelena; Mazibrada, Ilijana; Vekic, Jelena
• Is Part Of: Growth factors. Volume 38:Number 2(2020)
• Page Start: 120
• Page End: 126
• Publication Date: 2020-03-03
• Subjects: HB-EGF -- oxidative stress -- oxLDL -- paraoxonase 1 -- hsCRP; Growth factors -- Periodicals; Physiology -- Periodicals; 611
• DOI: 10.1080/08977194.2020.1841757
• Languages: English
• ISSNs: 0897-7194

Abstract

Abstract: Heparin-binding EGF-like growth factor (HB-EGF) is involved in atherosclerosis progression. We investigated association between plasma HB-EGF levels and lipid, oxidative stress and inflammatory biomarkers in pediatric patients with type 1 diabetes mellitus (T1DM). Levels of HB-EGF, high-sensitive C-reactive protein (hsCRP), prooxidant-antioxidant balance (PAB), total antioxidant status (TAS), oxidized low-density lipoproteins (oxLDL), metabolic control and serum lipid parameters and paraoxonase 1 (PON1) activity were determined in 74 patients and 40 controls. In comparison to controls, patients had significantly higher levels ( p < 0.01) of HB-EGF, hsCRP, PAB and oxLDL particles ( p < 0.001), but lower levels of TAS and PON1 activity. In T1DM group, HB-EFG levels were positively associated with hsCRP, PAB and oxLDL levels. hsCRP and oxLDL levels were independent predictors of HB-EGF concentration. We demonstrated that oxidative modifications of LDL particles and low-grade inflammation are main determinants of increased plasma HB-EGF levels, which indicates an interactive role of oxidative stress, dyslipidemia and inflammation.