Affective temperaments (TEMPS-A) in panic disorder and healthy probands: Genetic modulation by 5-HTT variation. (25th November 2020)

• Record Type: Journal Article
• Authors: Schiele, Miriam A.; Herzog, Katharina; Kollert, Leonie; Böhnlein, Joscha; Repple, Jonathan; Rosenkranz, Karoline; Leehr, Elisabeth J.; Ziegler, Christiane; Lueken, Ulrike; Dannlowski, Udo; Pauli, Paul; Arolt, Volker; Zwanzger, Peter; Deckert, Jürgen; Erfurth, Andreas; Domschke, Katharina
• Is Part Of: World journal of biological psychiatry. Volume 21:Number 10(2020)
• Page Start: 790
• Page End: 796
• Publication Date: 2020-11-25
• Subjects: Temperament -- TEMPS-A -- anxious -- anxiety disorders -- serotonin transporter; Biological psychiatry -- Periodicals; Biological Psychiatry -- Periodicals; 616.89
• DOI: 10.1080/15622975.2019.1705999
• Languages: English
• ISSNs: 1562-2975

Abstract

Abstract: Objectives: Temperamental traits as ascertained by the Temperament Evaluation of Memphis, Pisa, Paris and San Diego Auto-Questionnaire (TEMPS-A) have been suggested as promising intermediate phenotypes of mental disorders. In anxiety disorders, however, TEMPS scales and their genetic underpinnings are still understudied. Methods: TEMPS-A scores in 109 patients with panic disorder (PD) were compared to a sample of 536 healthy probands. All participants were genotyped for serotonin transporter gene variation ( 5-HTT LPR/rs25531). Results: PD patients displayed significantly increased scores on the dysthymic, cyclothymic, irritable and anxious subscales, and lower scores on the hyperthymic subscale, respectively (all ps < 0.001) compared to healthy probands. In the total sample, the less active 5-HTT LPR/rs25531 S/LG alleles were associated with higher scores on the dysthymic, cyclothymic, irritable and anxious temperaments (all ps < 0.01), but not the hyperthymic subscale. Mediation analyses revealed anxious temperament in particular to mediate the relationship between 5-HTT genotype and PD. Conclusions: Dysthymic, cyclothymic, irritable and notably anxious temperament could serve as valuable intermediate phenotypes in efforts to unravel neurobiological, particularly serotonin system related genetic pathomechanisms associated with PD and potentially contribute to a panel of vulnerability markers guiding early targeted preventive interventions.