Synthetic routes to rhodanine scaffolds. Issue 24 (16th December 2020)

• Record Type: Journal Article
• Authors: Kargar Razi, Maryam; Javahershenas, Ramin; Adelzadeh, Mehdi; Ghobadi, Massoud; Kazemi, Mosstafa
• Is Part Of: Synthetic communications. Volume 50:Issue 24(2020)
• Page Start: 3739
• Page End: 3756
• Publication Date: 2020-12-16
• Subjects: Medicinal chemistry -- rhodanine structural scaffolds -- S-heterocycles -- synthetic chemistry; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2020.1812658
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: Rhodanine structural scaffolds are an important class of sulfur-containing heterocycles with a broad spectrum of applications in medicinal chemistry. Highly functionalized piperidine scaffolds have shown profound impact in drug discovery research owing to its important bioactivity. The green and high-yielding synthesis of rhodanine structural scaffolds from readily available materials remains is a hot topic research for the synthetic chemistry community. In this review, we discuss the recent various synthetic procedures reported in the literature for the synthesis of rhodanine structural scaffolds. Graphical Abstract: Examples of biologically active rhodanine derivatives.