An alternate and efficient method for preparation of 2, 6-diacetamido-4-formylpyridine for formation of porphyrin appended with hydrogen bonding motifs. Issue 21 (1st November 2020)

• Record Type: Journal Article
• Authors: Singh, Sunaina; Aggarwal, Amit; Mercier, Phillippe H.; Bhupathiraju, N. V. S. Dinesh K.; Landress, Michael; Hanna, Keroles
• Is Part Of: Synthetic communications. Volume 50:Issue 21(2020)
• Page Start: 3256
• Page End: 3263
• Publication Date: 2020-11-01
• Subjects: Pyridine -- porphyrins -- supramolecular; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2020.1799012
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: We report here an alternate redesigned five-step synthesis of 2, 6-diacetamido-4-formylpyridine. The method described here is more convenient where this aldehyde is prepared in commercially viable quantities from simple and easy-to-use reagents and is a key compound required to prepare 5, 10, 15, 20-Tetrakis(3, 5-diacetamido-4-pyridyl)porphyrin (I). This porphyrin can be used as an excellent building block for the construction of supramolecular assemblies and is an interesting compound to study the design, principles, and photonic properties such as the extent of electron and energy transfer. Graphical Abstract: