Multifaceted regulation of translation by the epitranscriptomic modification N6-methyladenosine. (4th March 2021)

• Record Type: Journal Article
• Authors: Liu, Xiao-Min; Zhou, Jun
• Is Part Of: Critical reviews in biochemistry and molecular biology. Volume 56:Number 2(2021)
• Page Start: 137
• Page End: 148
• Publication Date: 2021-03-04
• Subjects: N6-methyladenosine -- translation regulation -- untranslated region -- coding region -- mRNA looping; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biochemistry -- Periodicals; Molecular Biology -- Periodicals; Review Literature -- Periodicals; 572
• DOI: 10.1080/10409238.2020.1869174
• Languages: English
• ISSNs: 1040-9238

Abstract

Abstract: Translation occurring on cytoplasmic mRNA is precisely governed at three consecutive stages, including initiation, elongation and termination. A growing body of evidence has revealed that an emerging epitranscriptomic code N 6 -methyladenosine (m 6 A), asymmetrically present in a large subset of coding and non-coding transcripts, is crucially required for mediating the translatomic stability. Through recruiting translation machinery proteins, serving as a physical barrier, or directing RNA structural rearrangement and mRNA looping formation, m 6 A has been decoded to modulate translational dynamics through potentially influencing the progress of different stages, thereby forming an additional layer of complexity to the regulation of translation. In this review, we summarize the current understanding of how m 6 A guides mRNA translation under normal and stress conditions, highlighting the divergent molecular mechanisms of multifarious regulation of m 6 A-mediated translation.