Clinical Features and Diagnosis of Anterior Segment Inflammation Related to Cytomegalovirus in Immunocompetent African, Asian, and Caucasian Patients. (2nd January 2021)

• Record Type: Journal Article
• Authors: Leleu, Igor; Jhanji, Vishal; Touhami, Sara; Westcott, Mark; Angi, Martina; Titah, Cherif; Rousseau, Antoine; Hamard, Pascale; Brasnu, Emmanuelle; Manicom, Thomas; Blumen-Ohana, Esther; Rozenberg, Flore; Vauloup-Fellous, Christelle; Deback, Claire; Labetoulle, Marc; Sahel, Jose-Alain; Bodaghi, Bahram; Merabet, Lilia; Kobal, Alfred; Brignole-Baudouin, Françoise; Errera, Marie-Hélène
• Is Part Of: Ocular immunology and inflammation. Volume 29:Number 1(2021)
• Page Start: 160
• Page End: 168
• Publication Date: 2021-01-02
• Subjects: HCMV -- uveitis -- endotheliitis -- Posner-Schlossman syndrome -- Fuchs heterochromic iridocyclitis -- polymerase chain reaction -- Goldmann-Witmer coefficient; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2019.1662059
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Objective : To report the clinical features and treatment outcomes in immunocompetent patients with anterior segment inflammation (ASI) related to human cytomegalovirus (HCMV) depending on their ethnic origin. Material and Methods : Multicenter retrospective study of 38 patients with at least one test, either HCMV-positive PCR or GWc. Results : Features of Posner-Schlossman syndrome were observed in 50% of the eyes, Fuchs heterochromic iridocyclitis in 13% of the eyes, chronic nonspecific anterior uveitis in 21% of the eyes, and corneal endotheliitis in 18% of the eyes. PCR and GWc were positive for HCMV in 50% and 96.2% of the eyes, respectively. Glaucoma was diagnosed in 50% of eyes. Treatment was oral valganciclovir in about half of the patients. Other treatments were intravenous ganciclovir and/or ganciclovir topical ointment and/or intravitreal ganciclovir. Conclusions : No obvious association of specific clinical features with individual ethnicity could be identified. We found a high rate of glaucoma in all ethnic groups. There was a delay in diagnosis and specific treatment of HCMV in most patients.