IL-1β and IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous Subtype. (12th February 2017)

• Record Type: Journal Article
• Authors: Wu, Yongkang; Cai, Bei; Zhang, Junlong; Shen, Beilei; Huang, Zhuochun; Tan, Chunyu; Baan, Carla C.; Wang, Lanlan
• Other Names: Egilmez Nejat K. Academic Editor.
• Is Part Of: Journal of immunology research. Volume 2017(2017)
• Publication Date: 2017-02-12
• Subjects: Immunology -- Periodicals; Immunology -- Research -- Periodicals; 616.07905
• DOI: 10.1155/2017/5096741
• Languages: English
• ISSNs: 2314-8861

Abstract

Abstract : Background. Systemic lupus erythematosus (SLE) is an autoimmune disease with great heterogeneity in pathogenesis and clinical symptoms. Rheumatoid factor (RF) is one key indicator for rheumatoid arthritis (RA) while immunoglobulin E (IgE) is associated with type I hypersensitivity. To better categorize SLE subtypes, we determined the dominant cytokines based on familial SLE patients. Methods. RF, IgE, and multiple cytokines (i.e., IL-1 β, IL-6, IL-8, IL-10, IL-17, IFN- γ, IP-10, MCP-1, and MIP-1 β ) were measured in sera of familial SLE patients (n = 3 ), noninherited SLE patients (n = 108 ), and healthy controls (n = 8 0 ). Results. Three familial SLE patients and 5 noninherited SLE cases are with features of RF+IgE+. These RF+IgE+ SLE patients expressed significantly higher levels of IL-1 β and IL-6 than the other SLE patients (P < 0 . 05 ). IL-6 correlated with both IgE and IL-1 β levels in RF+IgE+ SLE patients (r 2 = 0.583, P = 0.027 ; r 2 = 0.847, P = 0.001 ), and IgE also correlated with IL-1 β (r 2 = 0 . 567, P = 0.0 3 1 ). Conclusion. Both IL-1 β and IL-6 are highly expressed cytokines in RF+IgE+ SLE subtype which may be related to the pathogenesis of this special SLE subtype and provide accurate treatment strategy by neutralizing IL-1 β and IL-6.