Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery. (21st July 2015)

• Record Type: Journal Article
• Authors: Knežević, Nikola Ž.; Milenković, Sanja; Jović, Danica; Lazarevic, Slavica; Mrdjanović, Jasminka; Djordjevic, Aleksandar
• Other Names: Riveiro Antonio Academic Editor.
• Is Part Of: Advances in materials science and engineering. Volume 2015(2015)
• Publication Date: 2015-07-21
• Subjects: Materials science -- Periodicals; Materials science; Periodicals; 620.11
• DOI: 10.1155/2015/567350
• Languages: English
• ISSNs: 1687-8434

Abstract

Abstract : Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues.