Need to take special care of non-responders to hepatitis B vaccination among health-care workers, students and chronic patients. Issue 2 (1st February 2021)

• Record Type: Journal Article
• Authors: Bechini, Angela; Bonanni, Paolo; Grazzini, Maddalena; Paolini, Diana; Arcangeli, Giulio; Mucci, Nicola; Bini, Costanza; Tiscione, Emilia; Zanella, Beatrice; Boccalini, Sara
• Is Part Of: Human vaccines & immunotherapeutics. Volume 17:Issue 2(2021)
• Page Start: 580
• Page End: 582
• Publication Date: 2021-02-01
• Subjects: Hepatitis B -- vaccination -- healthcare workers -- chronic patients -- non-responders -- additional doses -- anti-HBs testing; Vaccines -- Periodicals; 615.372
• DOI: 10.1080/21645515.2020.1810495
• Languages: English
• ISSNs: 2164-5515

Abstract

ABSTRACT: Both our research and that published by Sticchi et al. on immunological memory against hepatitis B virus (HBV) in health-care workers (HCWs) vaccinated as infants or adolescents confirm that in those testing negative after the primary course, one additional (fourth) booster dose is able to elicit an anti-HBs response in >85% subjects. The fifth and the sixth doses further contribute substantially to a high overall response rate. The rate of subjects showing an anamnestic response after the booster dose was almost six-fold higher in HCWs compared to chronic patients. Since universal vaccination in Italy resulted in a significant decrease in HBV infections, special attention and testing should be addressed to those affected by chronic diseases.