PathSTORM: a road to early cancer detection. (2nd September 2020)

• Record Type: Journal Article
• Authors: Troy, Kris; Liu, Yang; Hainer, Sarah J.
• Is Part Of: Molecular & cellular oncology. Volume 7:Number 5(2020)
• Publication Date: 2020-09-02
• Subjects: PathSTORM -- chromatin -- CUT&RUN -- oncogenesis -- diagnostics; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2020.1776086
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.