Type 2 Diabetes in Young Females Results in Increased Serum Amyloid A and Changes to Features of High Density Lipoproteins in Both HDL2 and HDL3. (17th May 2017)

• Record Type: Journal Article
• Authors: Griffiths, Kayleigh; Pazderska, Agnieszka; Ahmed, Mohammed; McGowan, Anne; Maxwell, Alexander P.; McEneny, Jane; Gibney, James; McKay, Gareth J.
• Other Names: Wadsack Christian Academic Editor.
• Is Part Of: Journal of diabetes research. Volume 2017(2017)
• Publication Date: 2017-05-17
• Subjects: Diabetes -- Periodicals; Diabetes -- Pathophysiology -- Periodicals; Diabetes -- Prevention -- Periodicals; Diabetes -- Etiology -- Periodicals; Diabetes -- Epidemiology -- Periodicals; Diabetes -- Pathogenesis -- Periodicals; 616.462005
• DOI: 10.1155/2017/1314864
• Languages: English
• ISSNs: 2314-6745

Abstract

Abstract : Persons with type 2 diabetes mellitus (T2DM) have an elevated risk of atherosclerosis. High-density lipoproteins (HDL) normally protect against cardiovascular disease (CVD), but this may be attenuated by serum amyloid A (SAA). In a case-control study of young females, blood samples were compared between subjects with T2DM (n = 42 ) and individuals without T2DM (n = 42 ). SAA and apolipoprotein AI (apoAI) concentrations, paraoxonase-1 (PON-1), cholesteryl ester transfer protein (CETP), and lecithin-cholesterol acyltransferase (LCAT) activities were measured in the serum and/or HDL2 and HDL3 subfractions. SAA concentrations were higher in T2DM compared to controls: serum (30 mg/L (17, 68) versus 15 mg/L (7, 36); p = 0.002 ), HDL2 (1.0 mg/L (0.6, 2.2) versus 0.4 mg/L (0.2, 0.7); p < 0.001 ), and HDL3 (13 mg/L (8, 29) versus 6 mg/L (3, 13); p < 0.001 ). Serum-PON-1 activity was lower in T2DM compared to that in controls (38, 245 U/L (7025) versus 41, 109 U/L (5690); p = 0.043 ). CETP activity was higher in T2DM versus controls in HDL2 (232.6 μ mol/L (14.1) versus 217.1 μ mol/L (25.1); p = 0.001 ) and HDL3 (279.5 μ mol/L (17.7) versus 245.2 μ mol/L (41.2); p < 0.001 ). These results suggest that individuals with T2DM have increased SAA-related inflammation and dysfunctional HDL features. SAA may prove to be a useful biomarker in T2DM given its association with elevated CVD risk.