Immune Response to Rotavirus and Gluten Sensitivity. (15th March 2018)

• Record Type: Journal Article
• Authors: Puccetti, Antonio; Saverino, Daniele; Opri, Roberta; Gabrielli, Oretta; Zanoni, Giovanna; Pelosi, Andrea; Fiore, Piera Filomena; Moretta, Francesca; Lunardi, Claudio; Dolcino, Marzia
• Other Names: Jiao Peirong Academic Editor.
• Is Part Of: Journal of immunology research. Volume 2018(2018)
• Publication Date: 2018-03-15
• Subjects: Immunology -- Periodicals; Immunology -- Research -- Periodicals; 616.07905
• DOI: 10.1155/2018/9419204
• Languages: English
• ISSNs: 2314-8861

Abstract

Abstract : Rotavirus is a double-stranded RNA virus belonging to the family of Reoviridae . The virus is transmitted by the faecal-oral route and infects intestinal cells causing gastroenteritis. Rotaviruses are the main cause of severe acute diarrhoea in children less than 5 years of age worldwide. In our previous work we have shown a link between rotavirus infection and celiac disease. Nonceliac gluten sensitivity (NCGS) is emerging as new clinical entity lacking specific diagnostic biomarkers which has been reported to occur in 6–10% of the population. Clinical manifestations include gastrointestinal and/or extraintestinal symptoms which recede with gluten withdrawal. The pathogenesis of the disease is still unknown. Aim of this work is to clarify some aspects of its pathogenesis using a gene array approach. Our results suggest that NCGS may have an autoimmune origin. This is based both on gene expression data (i.e., TH17-interferon signatures) and on the presence of TH17 cells and of serological markers of autoimmunity in NCGS. Our results also indicate a possible involvement of rotavirus infection in the pathogenesis of nonceliac gluten sensitivity similarly to what we have previously shown in celiac disease.