Assessment of Serum Nitrogen Species and Inflammatory Parameters in Relapsing-Remitting Multiple Sclerosis Patients Treated with Different Therapeutic Approaches. (19th December 2016)

• Record Type: Journal Article
• Authors: Niedziela, Natalia; Adamczyk-Sowa, Monika; Niedziela, Jacek T.; Mazur, Bogdan; Kluczewska, Ewa; Sowa, Paweł; Gąsior, Mariusz
• Other Names: Kipp Markus Academic Editor.
• Is Part Of: BioMed research international. Volume 2016(2016)
• Publication Date: 2016-12-19
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2016/4570351
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : The role of nitric oxide and its reactive derivatives (N O x ) is well known in the pathogenesis of multiple sclerosis, which is an inflammatory disease while N O x seems to be important in coordinating inflammatory response. The purpose of the present study was to assess serum N O x as one of the nitrogen species and inflammatory parameters in relapsing-remitting multiple sclerosis patients and to compare the effectiveness of various types of disease-modifying therapies that reduce nitric oxide and inflammatory biomarkers. Elevated N O x level was observed in patients who received the first-line disease-modifying therapy (interferons beta-1a and beta-1b) in comparison with the subjects treated with the second-line disease-modifying therapy (natalizumab; fingolimod) and healthy controls without significant differences in C-reactive protein and interleukin-1 beta. A negative correlation was observed between serum N O x level and the duration of multiple sclerosis confirmed in the whole study population and in subjects treated with the first-line agents. Only serum N O x, concentration could reveal a potential efficacy of disease-modifying therapy with a better reduction in N O x level due to the second-line agents of disease-modifying therapy.