Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-κB Pathway. (14th September 2017)

• Record Type: Journal Article
• Authors: Yang, Jen-Tsung; Lee, I-Neng; Lu, Fung-Jou; Chung, Chiu-Yen; Lee, Ming-Hsueh; Cheng, Yu-Ching; Chen, Kuo-Tai; Chen, Ching-Hsein
• Other Names: Ortuño-Sahagún Daniel Academic Editor.
• Is Part Of: Journal of immunology research. Volume 2017(2017)
• Publication Date: 2017-09-14
• Subjects: Immunology -- Periodicals; Immunology -- Research -- Periodicals; 616.07905
• DOI: 10.1155/2017/9489383
• Languages: English
• ISSNs: 2314-8861

Abstract

Abstract : In this study, we demonstrated that temozolomide (TMZ) and propyl gallate (PG) combination enhanced the inhibition of migration in human U87MG glioma cells. PG inhibited the TMZ-induced reactive oxygen species (ROS) generation. The mitochondrial complex III and NADPH oxidase are two critical sites that can be considered to regulate antimigration in TMZ-treated U87MG cells. PG can enhance the antimigration effect of TMZ through suppression of metalloproteinase-2 and metalloproteinase-9 activities, ROS generation, and the NF- κ B pathway and possibly provide a novel prospective strategy for treating malignant glioma.