Estimating the Risk of ABO Hemolytic Disease of the Newborn in Lagos. (17th September 2015)

• Record Type: Journal Article
• Authors: Akanmu, Alani Sulaimon; Oyedeji, Olufemi Abiola; Adeyemo, Titilope Adenike; Ogbenna, Ann Abiola
• Other Names: Wendel Silvano Academic Editor.
• Is Part Of: Journal of blood transfusion. Volume 2015(2015)
• Publication Date: 2015-09-17
• Subjects: Blood -- Transfusion -- Periodicals; Blood Transfusion; Blood -- Transfusion; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; Electronic journals; 615.39
• DOI: 10.1155/2015/560738
• Languages: English
• ISSNs: 2090-9187

Abstract

Abstract : Background . ABO hemolytic disease of the newborn is the most common hemolytic consequence of maternofetal blood group incompatibility restricted mostly to non-group-O babies of group O mothers with immune anti-A or anti-B antibodies. Aim . We estimated the risk of ABO HDN with view to determining need for routine screening for ABO incompatibility between mother and fetus. Materials and Methods . Prevalence of ABO blood group phenotypes in blood donors at the donor clinic of the Lagos University Teaching Hospital and arithmetic methods were used to determine population prevalence of ABO genes. We then estimated proportion of pregnancies of group O mothers carrying a non-group-O baby and the risk that maternofetal ABO incompatibility will cause clinical ABO HDN. Results . Blood from 9138 donors was ABO typed. 54.3%, 23%, 19.4%, and 3.3% were blood groups O, A, B, and AB, respectively. Calculated gene frequencies were 0.1416, 0.1209, and 0.7375 for A, B, and O genes, respectively. It was estimated that 14.3% of deliveries will result in a blood group O woman giving birth to a child who is non-group-O. Approximately 4.3% of deliveries are likely to suffer ABO HDN with 2.7% prone to suffer from moderately severe to severe hemolysis.