Novel Synthetic Monothiourea Aspirin Derivatives Bearing Alkylated Amines as Potential Antimicrobial Agents. (22nd January 2017)

• Record Type: Journal Article
• Authors: Nordin, Norsyafikah Asyilla; Chai, Tchan Wei; Tan, Bee Ling; Choi, Ching Liang; Abd Halim, Ainaa Nadiah; Hussain, Hasnain; Ngaini, Zainab
• Other Names: Silva Artur M. S. Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2017(2017)
• Publication Date: 2017-01-22
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2017/2378186
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : A new series of aspirin bearing alkylated amines moieties 1 –12 were synthesised by reacting isothiocyanate with a series of aniline derivatives in overall yield of 16–56%. The proposed structures of all the synthesised compounds were confirmed using elemental analysis, FTIR, and 1 H and 13 C NMR spectroscopy. All compounds were evaluated for antibacterial activities against E. coli and S. aureus via turbidimetric kinetic and Kirby Bauer disc diffusion method. Compound 5 bearing meta -CH3 substituent showed the highest relative inhibition zone diameter against tested bacteria compared to ortho and para substituent. Furthermore, aspirin derivatives bearing shorter chains exhibited better bacterial inhibition than longer alkyl chains.