Hemoglobin Rothschild – Unimpaired physical performance and oxygen uptake – A case report with literature review. (2022)

• Record Type: Journal Article
• Authors: Fomenko, Alexey; Kolokowski, Thomas; Heyse, Detlev; Petkova, Polina; Hassan, Malak; Rezazadegan, Kaweh; Walther, Niklas; Dellweg, Dominic
• Is Part Of: Respiratory medicine case reports. Volume 38(2022)
• Publication Date: 2022
• Subjects: Hb variant -- Hb Rothschild -- VO₂ max -- Oxygen gap -- Pulse oximetry -- CO-oximetry; Respiratory organs -- Diseases -- Periodicals; Chest -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory System -- Periodicals; Chest -- Diseases; Respiratory organs -- Diseases; Electronic journals; Periodicals; 616.2
• DOI: 10.1016/j.rmcr.2022.101681
• Languages: English
• ISSNs: 2213-0071

Abstract

Abstract: Asymptomatic patients with hemoglobin (Hb) variants can be detected by low oxygen levels in pulse oximetry (SpO₂). Depending on the type of Hb variant, low SpO₂ values are either falsely low, with corresponding normal arterial oxygen saturation (SaO₂), or truly low, with low SaO₂ values, as observed in Hb variants with low oxygen binding affinity. In this context, attention must be paid to the method of determining SaO₂. Low oxygen affinity Hb variants such as Hb Rothschild (HbR) might compensate for low oxygen loading in the lung through unloading more oxygen in peripheral tissues. This is the first case report to illustrate that maximal oxygen uptake and the workload are unimpaired in HbR variant patients.