The Regulatory Role of Ferroptosis in Bone Homeostasis. (13th July 2022)

• Record Type: Journal Article
• Authors: Xiong, Yuan; Chen, Lang; Lin, Ze; Hu, Yiqiang; Panayi, Adriana C.; Zhou, Wu; Sun, Yun; Cao, Faqi; Liu, Guodong; Dai, Guangdong; Mi, Bobin; Liu, Guohui
• Other Names: Gao Bo Academic Editor.
• Is Part Of: Stem cells international. Volume 2022(2022)
• Publication Date: 2022-07-13
• Subjects: Stem Cells -- Periodicals; Stem Cells -- Therapeutic use -- Periodicals; Stem Cells -- Transplantation -- Periodicals; 616.0277405
• DOI: 10.1155/2022/3568597
• Languages: English
• ISSNs: 1687-966X

Abstract

Abstract : Ferroptosis is an iron-dependent form of programmed cell death and an important type of biological catabolism. Through the action of divalent iron or ester oxygenase, ferroptosis can induce lipid peroxidation and cell death, regulating a variety of physiological processes. The role of ferroptosis in the modulation of bone homeostasis is a significant topic of interest. Herein, we review and discuss recent studies exploring the mechanisms and functions of ferroptosis in different bone-related cells, including mesenchymal stem cells, osteoblasts, osteoclasts, and osteocytes. The association between ferroptosis and disorders of bone homeostasis is also explored in this review. Overall, we aim to provide a detailed overview of ferroptosis, summarizing recent understanding on its role in regulation of bone physiology and bone disease pathogenesis.