CircRNAs in lung cancer- role and clinical application. (28th September 2022)

• Record Type: Journal Article
• Authors: Li, Jingwei; Zhang, Qiran; Jiang, Decheng; Shao, Jun; Li, Weimin; Wang, Chengdi
• Is Part Of: Cancer letters. Volume 544(2022)
• Publication Date: 2022-09-28
• Subjects: Circular RNAs -- miRNA sponge -- Pathophysiology -- Biomarker; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2022.215810
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Lung cancer holds the highest mortality rate among malignancies worldwide. Nevertheless, the potential molecular mechanisms of its tumorigenesis and evolution remain obscure. Circular RNAs (circRNAs), a broad category of covalently closed molecules, follow a malignancy-restricted expression pattern. Leading-edge studies have demonstrated the clinical application prospects of circRNAs in lung cancer. Herein, this review elucidates the biogenesis, biological functions, and pathophysiology of circRNAs. Furthermore, we underscore the forefront of the diagnostic, prognostic, and therapeutic potential of circRNAs in lung cancer as well as discuss the bottleneck that needs to be overcome to translate the basic advances of circRNAs into clinical practice. Highlights: Biogenesis and biological functions of circRNAs. CircRNAs exert significant pathophysiological roles in tumorigenesis and evolution of lung cancer. Certain CircRNAs have diagnostic, prognostic, and therapeutic potentials in lung cancer.