Low-Frequency Pulsed Electromagnetic Field Is Able to Modulate miRNAs in an Experimental Cell Model of Alzheimer's Disease. (2nd May 2017)

• Record Type: Journal Article
• Authors: Capelli, Enrica; Torrisi, Filippo; Venturini, Letizia; Granato, Maria; Fassina, Lorenzo; Lupo, Giuseppe Francesco Damiano; Ricevuti, Giovanni
• Other Names: Lindén Maria Academic Editor.
• Is Part Of: Journal of healthcare engineering. Volume 2017(2017)
• Publication Date: 2017-05-02
• Subjects: Hospital buildings -- Environmental engineering -- Periodicals; Medical technology -- Periodicals; Medical informatics -- Periodicals; 610.28
• DOI: 10.1155/2017/2530270
• Languages: English
• ISSNs: 2040-2295

Abstract

Abstract : The aim of the present study was to investigate on the effects of a low-frequency pulsed electromagnetic field (LF-PEMF) in an experimental cell model of Alzheimer's disease (AD) to assess new therapies that counteract neurodegeneration. In recent scientific literature, it is documented that the deep brain stimulation via electromagnetic fields (EMFs) modulates the neurophysiological activity of the pathological circuits and produces clinical benefits in AD patients. EMFs are applied for tissue regeneration because of their ability to stimulate cell proliferation and immune functions via the HSP70 protein family. However, the effects of EMFs are still controversial and further investigations are required. Our results demonstrate the ability of our LF-PEMF to modulate gene expression in cell functions that are dysregulated in AD (i.e., BACE1) and that these effects can be modulated with different treatment conditions. Of relevance, we will focus on miRNAs regulating the pathways involved in brain degenerative disorders.