Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study. (16th August 2017)

• Record Type: Journal Article
• Authors: Kim, Jong Ho; Kim, Sang Soo; Kim, In Joo; Kim, Bo Hyun; Park, Ja Young; Lee, Chang Won; Suk, Ji Hye; Shin, Sun Hae; Son, Sung Pyo; Kim, Min Chul; Ahn, Jun Hyeob; Lee, Kwang Jae; Kwon, Min Jung; Lee, Soon Hee; Park, Jeong Hyun
• Other Names: Tura Andrea Academic Editor.
• Is Part Of: Journal of diabetes research. Volume 2017(2017)
• Publication Date: 2017-08-16
• Subjects: Diabetes -- Periodicals; Diabetes -- Pathophysiology -- Periodicals; Diabetes -- Prevention -- Periodicals; Diabetes -- Etiology -- Periodicals; Diabetes -- Epidemiology -- Periodicals; Diabetes -- Pathogenesis -- Periodicals; 616.462005
• DOI: 10.1155/2017/7047909
• Languages: English
• ISSNs: 2314-6745

Abstract

Abstract : Aim . The aim of this study was to evaluate the association between arterial stiffness and albuminuria and glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus. Methods . This multicenter cohort study analyzed 2613 patients with type 2 diabetes. Brachial-ankle pulse wave velocity (baPWV) was used as a noninvasive marker of arterial stiffness. Additionally, the patients were categorized into four groups according to their albumin-to-creatinine ratio (ACR, normoalbuminuria versus albuminuria) and estimated GFR (eGFR, <60 mL/min/1.73 m 2 versus ≥60 mL/min/1.73 m 2 ). Results . A univariate analysis revealed that maximal baPWV was significantly associated with both the ACR (r = 0.297, P < 0.001 ) and eGFR (r = − 0.220, P < 0.001 ). A multivariate analysis adjusted for significant clinical variables and eGFR showed that baPWV remained significantly correlated with the ACR (r = 0.150, P < 0.001 ). Also, baPWV was correlated positively with the ACR in patients with an eGFR ≥ 60 mL/min/1.73 m 2 (r = 0.146, P < 0.001 ). However, baPWV was not correlated with eGFR after adjustment for significant clinical variables. Conclusions . The present findings indicate that arterial stiffness is more associated with albuminuria than a decrease in GFR in patients with type 2 diabetes mellitus.