Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation. (12th August 2018)

• Record Type: Journal Article
• Authors: Pinacchio, Claudia; Scheri, Giuseppe Corano; Statzu, Maura; Santinelli, Letizia; Ceccarelli, Giancarlo; Innocenti, Giuseppe Pietro; Vullo, Vincenzo; Antonelli, Guido; Brenchley, Jason M.; d'Ettorre, Gabriella; Scagnolari, Carolina
• Other Names: Nistico Paola Academic Editor.
• Is Part Of: Journal of immunology research. Volume 2018(2018)
• Publication Date: 2018-08-12
• Subjects: Immunology -- Periodicals; Immunology -- Research -- Periodicals; 616.07905
• DOI: 10.1155/2018/1738676
• Languages: English
• ISSNs: 2314-8861

Abstract

Abstract : Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic supplementation. IFN α subtypes and IFN β were expressed at higher levels in GALT compared to PBMC, whereas an opposite trend of expression was recorded for IFN γ . An increase of IFN α 6, IFN α 10, IFN α 14, IFN α 17, and IFN α 21 and a decrease of IFN γ were observed in both anatomical sites after probiotic supplementation.