Advances in disease-modifying pharmacotherapies for the treatment of amyotrophic lateral sclerosis. (12th June 2020)

• Record Type: Journal Article
• Authors: Hergesheimer, R; Lanznaster, D; Vourc'h, P; Andres, Cr; Bakkouche, Se; Beltran, S; Blasco, H; Corcia, P; Couratier, P
• Is Part Of: Expert opinion on pharmacotherapy. Volume 21:Number 9(2020)
• Page Start: 1103
• Page End: 1110
• Publication Date: 2020-06-12
• Subjects: ALS -- dexpramipexole -- edaravone -- biomarkers -- clinical staging -- personalized medicine; Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1080/14656566.2020.1746270
• Languages: English
• ISSNs: 1465-6566

Abstract

ABSTRACT: Introduction: To date, riluzole and edaravone are the only two drugs that have successfully passed clinical trials for the treatment of Amyotrophic Lateral Sclerosis (ALS). Unfortunately, both drugs exhibit very modest effects. Most other drugs have failed at phase III to show significant effects in phase III when tested in larger cohorts. This pattern necessitates improvements in the approach to ALS pharmacotherapy. Areas covered: The authors discuss the two approved drugs, as well as several examples of drug candidates whose clinical trials did not demonstrate efficacy in phase III. Post-hoc analyses reveal that future clinical trials should include disease-staging procedures, longer-term trials to correctly assess survival, genetic studies of participants to aid in stratification, and more similarity between the protocols on preclinical models and clinical trials. Finally, they discuss the trials in process that demonstrate some of these suggestions and improvements. Expert opinion: The approval of riluzole and edaravone was essentially a desperate attempt to provide urgent pharmacotherapy to the ALS community. To evolve toward more efficient therapies, we must conduct clinical trials with optimal stratification based on rapid/slow progressors and cognitive decline. Pharmaco-metabolomics should allow for the identification of biomarkers that are adapted for a given drug.