Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals. (16th December 2018)

• Record Type: Journal Article
• Authors: Lee, Bonggi; Moon, Kyoung Mi; Kim, Choon Young
• Other Names: Egilmez Nejat K. Academic Editor.
• Is Part Of: Journal of immunology research. Volume 2018(2018)
• Publication Date: 2018-12-16
• Subjects: Immunology -- Periodicals; Immunology -- Research -- Periodicals; 616.07905
• DOI: 10.1155/2018/2645465
• Languages: English
• ISSNs: 2314-8861

Abstract

Abstract : The intestine plays an essential role in integrating immunity and nutrient digestion and absorption. Adjacent intestinal epithelia form tight junctions (TJs) that are essential to the function of the physical intestinal barrier, regulating the paracellular movement of various substances including ions, solutes, and water across the intestinal epithelium. Studies have shown that TJ dysfunction is highly associated with metabolic and inflammatory diseases. Thus, molecular and nutritional factors that improve TJ activity have gained attention in the pharmaceutical and medicinal fields. This review focuses on the association between TJ and diverse pathological conditions, as well as various molecular and nutritional interventions designed to boost TJ integrity.