Translation control can shape TP53-dependent cell fate. (2nd September 2020)

• Record Type: Journal Article
• Authors: Rizzotto, Dario; Zaccara, Sara; Rossi, Annalisa; Dassi, Erik; Inga, Alberto
• Is Part Of: Molecular & cellular oncology. Volume 7:Number 5(2020)
• Publication Date: 2020-09-02
• Subjects: p53 -- DHX30 -- PCBP2 -- apoptosis -- transcription -- translation -- polysomal profiling -- translatome; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2020.1767483
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: The search for mechanisms underlying different cellular responses to the treatment with Nutlin-3, an MDM2 inhibitor that unleashes p53, revealed a translational control mechanism involving the RNA binding proteins PCBP2 and, particularly, DHX30. Sifting through a multi-functional p53-dependent transcriptional output, this translational control can modulate the activation of cell death pathways.