Thinner Corneas Appear to Have More Striking Effects of Corneal Collagen Crosslinking in Patients with Progressive Keratoconus. (14th March 2017)

• Record Type: Journal Article
• Authors: Han, Yunfei; Xu, Yanyun; Zhu, Wei; Liu, Yuling; Liu, Zhen; Dou, Xiaoxiao; Mu, Guoying
• Other Names: Sandner Dirk Academic Editor.
• Is Part Of: Journal of ophthalmology. Volume 2017(2017)
• Publication Date: 2017-03-14
• Subjects: Ophthalmology -- Periodicals; Eye Diseases; Ophthalmology; Ophthalmology; Electronic journals; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 617.7
• DOI: 10.1155/2017/6490915
• Languages: English
• ISSNs: 2090-004X

Abstract

Abstract : Purpose. To analyze the outcomes and difference after UVA/riboflavin corneal collagen crosslinking (CXL) in four different corneal thickness groups of patients with progressive keratoconus. Methods. Retrospective study. Eyes with progressive keratoconus after CXL were divided into 4 subgroups as follows: group 1, thinnest corneal thickness (TCT) ≤ 400 µ m; group 2, 400 µ m < TCT ≤ 450 µ m; group 3, 450 µ m < TCT ≤ 500 µ m; group 4, TCT ≥ 500 µ m. Baseline, 6-month, and 12-month visual acuity, corneal topography, TCT, and endothelial cell density were evaluated. Results. The analysis included 123 eyes of 101 patients. At 6 and 12 months after CXL, there was a mean improvement about visual acuity and keratometry values in all patients. There was a reduction in the change of maximum keratometry ( K max ) with the increase of TCT. After 1 year of treatment, it was 3.04 ± 0.75 D in group 1, 2.38 ± 0.51 D in group 2, 1.57 ± 0.35 D in group 3, and 0.31 ± 0.20 D in group 4. Conclusion. CXL is successful in halting the progression of keratoconus and there was a negative linear correlation between TCT and K max . Advanced cases of progressive keratoconus seemed to obtain more benefits from the flatting effects of CXL.