Associations of Sleep Measures with Retinal Microvascular Diameters among Police Officers. (1st November 2020)

• Record Type: Journal Article
• Authors: Ma, Claudia C; Gu, Ja K; Andrew, Michael E; Fekedulegn, Desta; Violanti, John M; Klein, Barbara; Tinney-Zara, Cathy; Charles, Luenda E
• Is Part Of: Ophthalmic epidemiology. Volume 27:Number 6(2020)
• Page Start: 487
• Page End: 497
• Publication Date: 2020-11-01
• Subjects: Actigraphy -- fundus photography -- police officer -- retinal microvasculature -- sleep quality; Blindness -- Prevention -- Periodicals; Eye -- Diseases -- Epidemiology -- Periodicals; Ophthalmology -- Periodicals; 614.5997
• DOI: 10.1080/09286586.2020.1783688
• Languages: English
• ISSNs: 0928-6586

Abstract

ABSTRACT: Purpose: We examined cross-sectional associations of sleep measures with central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) and investigated whether sex and race/ethnicity modified these associations. Methods: Participants (N = 202; 78% white; 71% men) were enrolled in the Buffalo Cardio-metabolic Occupational Police Stress study (2011–2014). Wrist actigraphy was used to assess sleep measures including sleep duration, sleep efficiency, sleep onset latency, wake after sleep onset, number of awakenings, and longest wake episode. CRAE and CRVE were obtained from fundus photography of retina and were averaged from both eyes per officer. Results: We observed significant associations between sleep efficiency and CRVE (β = -2.81 µm; P = .046), and between longest wake episode and CRVE (β = 3.24 µm; P = .021). Adjustments for demographics, lifestyles, and physical and psychological factors attenuated these associations. Sex modified the independent associations of sleep onset latency and longest wake episode with CRVE. One standard deviation (SD) increase in sleep onset latency was associated with 4.81 µm larger CRVE ( P = .028) ( P -interaction = 0.098), and one SD increase in longest wake episode was associated with 4.62 µm larger CRVE ( P = .032) ( P -interaction = 0.115) among men. Race/ethnicity also modified the association between longest wake episode and CRVE ( P -interaction = 0.088). A significant association was observed only among white officers (β = 4.96 µm; P = .025). Conclusions: We found that poor sleep quality, measured by longest wake episode, was positively and independently associated with retinal venular diameter among white and male officers. Longitudinal studies are warranted to assess whether poor sleep quality is a risk factor for retinal diameter changes.