Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection. (19th January 2016)

• Record Type: Journal Article
• Authors: Lima, Clara Mônica; Santos, Silvane; Dourado, Adriana; Carvalho, Natália B.; Bittencourt, Valéria; Lessa, Marcus Miranda; Siqueira, Isadora; Carvalho, Edgar M.
• Other Names: Maggi Enrico Academic Editor.
• Is Part Of: Journal of immunology research. Volume 2016(2016)
• Publication Date: 2016-01-19
• Subjects: Immunology -- Periodicals; Immunology -- Research -- Periodicals; 616.07905
• DOI: 10.1155/2016/8402059
• Languages: English
• ISSNs: 2314-8861

Abstract

Abstract : The Sjögren syndrome has been diagnosed in patients with HTLV-1 associated myelopathy and dry mouth and dry eyes are documented in HTLV-1 carriers. However the diagnosis of Sjögren syndrome in these subjects has been contested. In this cross-sectional study, we evaluated the role of immunological factors and proviral load, in sicca syndrome associated with HTLV-1 in patients without myelopathy. Subjects were recruited in the HTLV-1 Clinic, from 2009 to 2011. The proviral load and cytokine levels (IFN- γ, TNF- α, IL-5, and IL-10) were obtained from a database containing the values presented by the subjects at admission in the clinic. Of the 272 participants, 59 (21.7%) had sicca syndrome and in all of them anti- Sjögren syndrome related antigen A (SSA) and antigen B (SSB) were negatives. The production of TNF- α and IFN- γ was higher in the group with sicca syndrome (P < 0.05 ) than in HTLV-1 infected subjects without sicca syndrome. Our data indicates that patients with sicca syndrome associated with HTLV-1 do not have Sjögren syndrome. However the increased production of TNF- α and IFN- γ in this group of patients may contribute to the pathogenesis of sicca syndrome associated with HTLV-1.