Biochemical Effects of Xylazine, Propofol, and Ketamine in West African Dwarf Goats. (11th September 2014)

• Record Type: Journal Article
• Authors: Celestine Okwudili, Ukwueze; Athanasius Chinedu, Eze; Jonas Anayo, Ona
• Other Names: Mestorino Nora Academic Editor.
• Is Part Of: Journal of veterinary medicine. Volume 2014(2014)
• Publication Date: 2014-09-11
• Subjects: Veterinary medicine -- Periodicals; 636.08905
• DOI: 10.1155/2014/758581
• Languages: English
• ISSNs: 2356-7708

Abstract

Abstract : Anaesthesia was induced in West African Dwarf (WAD) goats using different combinations of propofol (P), xylazine (X), and ketamine (K), and the biochemical effect of the drugs determined. Twenty male (WAD) goats were randomly assigned to five treatment groups viz. Control (C) (2.5 mL IV normal saline); group K + X (5 mg/kg IV ketamine + 0.05 mg/kg IV xylazine), group P + X (5 mg/kg IV propofol + 0.05 mg/kg IV xylazine), group P + K (propofol 5 mg/kg IV + ketamine 5 mg/kg IV), and group P + K + X (propofol 2.5 mg/kg IV + ketamine 2.5 mg/kg IV + xylazine 0.05 mg/kg IV), respectively. There was increase (P < 0.05 ) in blood glucose in K + X, P + X and P + K + X. The serum cortisol level increased (P < 0.05 ) in all groups except in P + X. ALT value increased (P < 0.05 ) in K + X, P + K, and P + K + X. BUN increased (P < 0.05 ) in K + X but decreased (P < 0.05 ) in P + K + X. There was no significant variation (P > 0.05 ) in serum creatinine. These biochemical changes were transient. P + K + X would be the best drug combinations considering the biochemical parameter measured. However, data on blood glucose, ALT, BUN, and cortisol levels in an anaesthsized goat should be interpreted with caution in order to avoid erroneous interpretation in these animals.