The Role of Adjunctive Therapies in Septic Shock by Gram Negative MDR/XDR Infections. (9th July 2017)

• Record Type: Journal Article
• Authors: Busani, Stefano; Roat, Erika; Serafini, Giulia; Mantovani, Elena; Biagioni, Emanuela; Girardis, Massimo
• Other Names: Oliva Alessandra Academic Editor.
• Is Part Of: Canadian journal of infectious diseases & medical microbiology =. Volume 2017(2017)
• Publication Date: 2017-07-09
• Subjects: Communicable diseases -- Periodicals; Infection -- Periodicals; Communicable diseases; Infection; Communicable Diseases; Communicable Disease Control; Electronic journals; Periodicals; Fulltext; Internet Resources; Periodicals; 616.9
• DOI: 10.1155/2017/2808203
• Languages: English
• ISSNs: 1712-9532

Abstract

Abstract : Patients with septic shock by multidrug resistant microorganisms (MDR) are a specific sepsis population with a high mortality risk. The exposure to an initial inappropriate empiric antibiotic therapy has been considered responsible for the increased mortality, although other factors such as immune-paralysis seem to play a pivotal role. Therefore, beyond conventional early antibiotic therapy and fluid resuscitation, this population may benefit from the use of alternative strategies aimed at supporting the immune system. In this review we present an overview of the relationship between MDR infections and immune response and focus on the rationale and the clinical data available on the possible adjunctive immunotherapies, including blood purification techniques and different pharmacological approaches.