A Transdermal Measurement Platform Based on Microfluidics. (25th December 2017)

• Record Type: Journal Article
• Authors: Huang, Wen-Ying; Huang, Jung-Ping; Lin, Chia-Ching; Lin, Yung-Sheng
• Other Names: Tavano Lorena Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2017(2017)
• Publication Date: 2017-12-25
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2017/9343824
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : The Franz diffusion cell is one of the most widely used devices to evaluate transdermal drug delivery. However, this static and nonflowing system has some limitations, such as a relatively large solution volume and skin area and the development of gas bubbles during sampling. To overcome these disadvantages, this study provides a proof of concept for miniaturizing models of transdermal delivery by using a microfluidic chip combined with a diffusion cell. The proposed diffusion microchip system requires only 80 μ L of sample solution and provides flow circulation. Two model compounds, Coomassie Brilliant Blue G-250 and potassium ferricyanide, were successfully tested for transdermal delivery experiments. The diffusion rate is high for a high sample concentration or a large membrane pore size. The developed diffusion microchip system, which is feasible, can be applied for transdermal measurement in the future.