Application of 19F NMR Spectroscopy for Content Determination of Fluorinated Pharmaceuticals. (18th October 2017)

• Record Type: Journal Article
• Authors: Okaru, Alex O.; Brunner, Tobias S.; Ackermann, Svenja M.; Kuballa, Thomas; Walch, Stephan G.; Kohl-Himmelseher, Matthias; Lachenmeier, Dirk W.
• Other Names: Esteve-Romero Josep Academic Editor.
• Is Part Of: Journal of analytical methods in chemistry. Volume 2017(2017)
• Publication Date: 2017-10-18
• Subjects: Chemistry, Analytic -- Periodicals; Chemistry, Analytic -- Technique -- Periodicals; 543.05
• DOI: 10.1155/2017/9206297
• Languages: English
• ISSNs: 2090-8865

Abstract

Abstract : A simple, rapid, and selective quantitative nuclear magnetic resonance spectroscopic method was evaluated for the determination of the content of fluorinated pharmaceuticals. 19 F NMR spectra were either obtained in dimethylsulfoxide- d 6 or aqueous buffer, using trifluoroacetic acid as internal standard. Quantification of 13 fluorine-containing pharmaceuticals spanning various pharmacological classes was accomplished using the proposed method. The method was found to be fit for purpose (interday precision 1.2% relative standard deviation) and may thus be applied for routine analysis and quality control of fluorine-containing pharmaceuticals due to its simplicity, nondestructive sample measurement, reliability, and high specificity. Therefore, 19 F NMR may serve as a suitable analytical tool for the identification and selective determination of fluorinated pharmaceuticals used as reference materials and bulk samples.