Neuroprotective Activity of Water Soluble Extract from Chorispora bungeana against Focal Cerebral Ischemic/Reperfusion Injury in Mice. (23rd June 2014)

• Record Type: Journal Article
• Authors: Sun, Ya-Xuan; Liu, Ting; Dai, Xue-Ling; Li, Ya-Bo; Li, Yu-Yao; Zhang, Hua; An, Li-Zhe
• Other Names: Zheng Qiusheng Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2014(2014)
• Publication Date: 2014-06-23
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2014/373872
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : The purpose of the present study was to clarify whether the water extract of Chorispora bungeana was an antioxidant agent against cerebral ischemia/reperfusion (I/R). Our results showed that water extract of Chorispora bungeana treatment significantly reduced neurological deficit scores, infarct size, MDA and carbonyl contents, and GSH/GSSG ratio compared with the model control group. After being treated by Chorispora bungeana, SOD, CAT, and GSH-Px activities remarkably increased. Chorispora bungeana treatment also improved 8-OHdG expression and cell apoptosis. Our findings indicated that the water extract of Chorispora bungeana possesses neuroprotective effect which is most likely achieved by antioxidant and antiapoptotic activities.