The Use of Coupled Plasma Filtration Adsorption in Traumatic Rhabdomyolysis. (19th March 2017)

• Record Type: Journal Article
• Authors: Pezzi, Mario; Renda, Silvia; Giglio, Anna Maria; Scozzafava, Anna Maria; Tiburzi, Simona Paola; Casella, Patrizia; Iannelli, Fabrizio; Verre, Mario
• Other Names: Nin Nicolas Academic Editor.
• Is Part Of: Case reports in critical care. Volume 2017(2017)
• Publication Date: 2017-03-19
• Subjects: Critical care medicine -- Periodicals; Emergency medicine -- Periodicals; Medical emergencies -- Periodicals; 616.02805
• DOI: 10.1155/2017/5764961
• Languages: English
• ISSNs: 2090-6420

Abstract

Abstract : Severe musculoskeletal injuries induce the release of sarcoplasmic elements such as muscle enzymes, potassium, and myoglobin in the systemic circulation. The circulating myoglobin damages the glomerulus and renal tubules. Conventional haemodialysis is not able to remove myoglobin, due to its high molecular weight (17, 8 kilodaltons [kDa]). We treated four traumatic rhabdomyolysis patients with Coupled Plasma Filtration Adsorption (CPFA) in order to remove myoglobin followed by 14 hours of Continuous Veno-Venous Hemofiltration (CVVH). During the treatment, all patients showed clinical improvement with a decrease in muscular (creatine kinase [CK] and myoglobin) and renal (creatinine and potassium) damage indices. One patient, in spite of full renal recovery, died of cerebral haemorrhage on the 26th day of hospital stay.