Synthesis of Mono‐fluoroallenes through Copper‐Catalyzed Defluorinative Silylation of α, α‐Difluoroalkylalkynes. Issue 17 (20th June 2022)

• Record Type: Journal Article
• Authors: Tang, Luning; Pei, Bing‐Bing; Song, Yang; Xue, Fei; Yue, Yanni; Feng, Chao
• Is Part Of: Chinese journal of chemistry. Volume 40:Issue 17(2022)
• Page Start: 2035
• Page End: 2039
• Publication Date: 2022-06-20
• Subjects: Allenes -- Copper -- Defluorination -- Silylation -- α, α‐Difluoroalkylalkyne; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.202200138
• Languages: English
• ISSNs: 1001-604X

Abstract

Comprehensive Summary: A straightforward protocol for the synthesis of mono‐fluorinated allenes via catalytic defluorinative silylation of the readily available α, α‐difluoroalkylalkynes with commercially available copper catalyst and phosphine ligand is described. A broad scope of α, α‐difluoroalkylalkynes were well accommodated and a gram‐scale synthesis demonstrated the synthetic utility of this methodoglogy. Abstract : A Cu‐catalyzed defluorinative silylation of readily available α, α‐difluoroalkylalkynes to access valuable mono‐fluoroallenes under mild conditions was developed.