Front Cover: Advances towards Cell‐Specific Gene Transfection: A Small‐Molecule Approach Allows Order‐of‐Magnitude Selectivity (Chem. Eur. J. 43/2022). Issue 43 (13th July 2022)

• Record Type: Journal Article
• Authors: Dirksmeyer, Thies; Stahl, Paul; Vallet, Cecilia; Knauer, Shirley; Giese, Michael; Schmuck, Carsten; Hirschhäuser, Christoph
• Is Part Of: Chemistry. Volume 28:Issue 43(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-13
• Subjects: biotin -- cancer cell targeting -- cell-penetrating peptides -- gene technology -- small molecules; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202202021
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : A biotin‐labelled transfection vector tightly grabs a DNA molecule with a binding unit of similar size to the label. At the same time, a cancer cell scans the label with its biotin receptor. While this will prompt the greedy cancer cell to be transfected by the DNA vector system, other cells are safe. And you can feel just as safe, if you want to use your smartphone and a scanner app in order to check out what information is hidden behind the QR code. More information can be found in the Research Article by C. Hirschhäuser et al. (DOI: 10.1002/chem.202104618 ).