Detection rate and variables associated with incidental prostate cancer by holmium laser enucleation of the prostate. (18th May 2022)

• Record Type: Journal Article
• Authors: Banno, Taro; Nakamura, Kazutaka; Kaneda, Yudai; Ozaki, Akihiko; Kouchi, Yukiko; Ohira, Tadashi; Shimmura, Hiroaki
• Is Part Of: International journal of urology. Volume 29:Number 8(2022)
• Page Start: 860
• Page End: 865
• Publication Date: 2022-05-18
• Subjects: prostate‐specific antigen -- prostatic hyperplasia -- prostatic neoplasms -- urologic surgery procedures -- urology; Urology -- Periodicals; Genitourinary organs -- Periodicals; Urologic Diseases -- Periodicals; 616.6005
• DOI: 10.1111/iju.14917
• Languages: English
• ISSNs: 0919-8172

Abstract

Abstract : Objectives: Holmium laser enucleation of the prostate is well‐established and effective for bladder outlet obstruction due to benign prostatic hyperplasia. The objective of this study was to examine the detection rate of incidental prostate cancer by holmium laser enucleation of the prostate and variables associated with them. Methods: A total of 612 patients were enrolled. We retrospectively examined the detection rate of incidental prostate cancer and perioperative variables associated with them. Results: Forty‐nine of 612 patients were diagnosed with incidental prostate cancer. Univariate logistic regression analysis showed that higher prostate‐specific antigen density (odds ratio 3.34, 95% confidence interval 1.02–10.94, P = 0.05), higher prostate‐specific antigen density of the transition zone (odds ratio 2.28, 95% confidence interval 1.02–5.09, P = 0.04), and findings of the prostate cancer on magnetic resonance imaging (peripheral zone: odds ratio 4.71, 95% confidence interval 1.70–13.1, P = 0.003; transition zone: odds ratio 3.46, 95% confidence interval 1.74–6.86, P < 0.001; peripheral and transition zones: odds ratio 6.00, 95% confidence interval 1.51–23.8, P = 0.01) were significantly associated with incidental prostate cancer. Multivariate logistic regression analysis showed that findings of the prostate cancer on magnetic resonance imaging (peripheral zone: odds ratio 4.36, 95% confidence interval 1.49–12.8, P = 0.001; transition zone: odds ratio 3.54, 95% confidence interval 1.75–7.16, P < 0.001; peripheral and transition zones: odds ratio 6.14, 95% confidence interval 1.53–24.5, P = 0.01) was an independent risk factor for incidental prostate cancer. Conclusion: The detection rate of incidental prostate cancer was 8.0%, and findings of the prostate cancer on magnetic resonance imaging were an independent predictive factor for incidental prostate cancer.