MO685: Brain Oxygenation Assessed by Near-Infrared Spectroscopy During a Mental Task and a Mild Physical Stress in Hemodialysis and Peritoneal Dialysis. (3rd May 2022)

• Record Type: Journal Article
• Authors: Faitatzidou, Danai; Dipla, Konstantina; Zafeiridis, Andreas; Theodorakopoulou, Marieta; Koutlas, Aggelos; Polychronidou, Georgia; Chalkidis, Georgios; Dimitriadis, Chrysostomos; Tsouchnikas, Ioannis; Giamalis, Panagiotis; Papagianni, Aikaterini; Sarafidis, Pantelis
• Is Part Of: Nephrology dialysis transplantation. Volume 37(2022)Supplement 3
• Publication Date: 2022-05-03
• Subjects: Nephrology -- Periodicals; Hemodialysis -- Periodicals; Kidneys -- Transplantation -- Periodicals; Hemodialysis; Kidneys -- Transplantation; Nephrology; Periodicals; 616.61
• DOI: 10.1093/ndt/gfac078.022
• Languages: English
• ISSNs: 0931-0509

Abstract

Abstract: BACKGROUND AND AIMS: Cognitive impairment is highly prevalent in end-stage kidney disease (ESKD) individuals. Brain oxygenation is a parameter that plays major role in cognitive function. This study aimed to examine for the first time changes in brain oxygenation during a mental and a mild physical task in hemodialysis (HD) and peritoneal dialysis (PD) patients. METHOD: A total of 63 ESKD patients (≥18 years old) were enrolled in this cross-sectional study. Patients were allocated in two groups according to dialysis modality ( n = 29 HD and n = 34 PD). All participants underwent a mental (countdown from 100 to 0 by 7, performed twice) and a mild physical task (a 3-min intermittent handgrip exercise at 35% of maximal handgrip strength). Changes in brain oxygenation [oxy—(O2Hb), deoxy—(HHb) and total—(tHb) hemoglobin] during the two tasks were continuously recorded via near-infrared spectroscopy (NIRS, Artinis). RESULTS: Age, sex and dialysis vintage did not differ between the two groups. The average response in brain oxygenation during the mental task (O2Hb change from rest: 1.51 ± 1.68 versus 1.60 ± 1.82 μmol, in HD and PD, respectively, P = 0.841), as well as the duration needed for task completion (191.53 ± 124.27 versus 200.19 ± 118.84 s, P = 0.781) were similar between groups. Furthermore, the average response in brain oxygenation during the handgrip exercise also did not differ between the groups (O2Hb change 1.20 ± 1.03 versus 1.49 ± 0.95 μmol, respectively, P = 0.262). In the total cohort, the average response in brain oxygenation during handgrip exercise was inversely correlated with dialysis vintage (P < 0.05). CONCLUSION: Dialysis modality does not appear to have an impact on brain oxygenation, as HD and PD patients presented similar responses during a mental and a mild physical task. Dialysis vintage may negatively affect brain oxygenation in ESKD individuals.