Propylphosphonic anhydride (T3P®)-mediated synthesis of redox-active N-(acyloxy)phthalimides. (17th August 2022)

• Record Type: Journal Article
• Authors: Tóth, Bálint; Szabó, Tímea; Volk, Balázs; Milen, Mátyás
• Is Part Of: Tetrahedron letters. Volume 104(2022)
• Publication Date: 2022-08-17
• Subjects: N-acyloxyphthalimides -- Redox-active esters -- Propylphosphonic anhydride -- N-hydroxyphthalimide; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.154016
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: Here, we report the novel synthesis of N -(acyloxy)phthalimides and their analogues as redox-active esters in the presence of propylphosphonic anhydride (T3P®) reagent using 2-methyltetrahydrofuran as a green solvent under mild reaction conditions. Our convenient technique provides a chromatography-free access to these remarkable synthetic intermediates with a wide substrate scope. By using our synthetic method, a variety of alkyl, aryl, arylalkyl and heteroaryl derivatives have been prepared.