MO142: Urinary Hemopexin  As a Marker of Lupus Activity Among Egyptian SLE Patients with Proliferative Lupus Nephritis. (3rd May 2022)

• Record Type: Journal Article
• Authors: Sabry, Alaa; Mahmoud, Rasha
• Is Part Of: Nephrology dialysis transplantation. Volume 37(2022)Supplement 3
• Publication Date: 2022-05-03
• Subjects: Nephrology -- Periodicals; Hemodialysis -- Periodicals; Kidneys -- Transplantation -- Periodicals; Hemodialysis; Kidneys -- Transplantation; Nephrology; Periodicals; 616.61
• DOI: 10.1093/ndt/gfac066.044
• Languages: English
• ISSNs: 0931-0509

Abstract

Abstract: BACKGROUND AND AIMS: To assess the role of urinary hemopexin in prediction of active lupus nephritis (LN) and correlate its level with disease activity and ability to predict response to induction therapy in Egyptian SLE patients with nephritis. METHOD: A cohort case-control hybrid study included patients diagnosed as LN and were recruited during 1 year from the from nephrology department in Mansoura University Hospital (from year 2017 to 2018). Forty-four patients (2 males and 42 females) and 22 control subjects were included. They were divided into three groups. Group I : patients with active LN, group II : SLE patients without LN and group III: healthy control. All participants were subjected to full history taking, Laboratory investigations such as ANA, anti-dsDNA, serum C3, C4, 24-h urinary protein, serum and urinary creatinine and urinary haemopexin. Renal biopsies were done in those with LN if not contraindicated. Patients received induction therapy according to the KDIGO guidelines. Urinary haemopexin was repeated after 6 months of induction therapy in LN patients. RESULTS: Urinary hemopexin was statistically higher in LN cases (11.85) IU/L compared to SLE without nephritis (4.84) IU/L and (3.63) IU/L in heathy subjects. There was a positive correlation between urinary haemopexin and proteinuria. Its level also significantly decreased after induction therapy. CONCLUSION: Haemopexin level is higher in LN than SLE without nephritis and its level decreases after immune suppression. Its level correlates with disease activity However, it cannot replace the role of renal biopsy.