Metabolic syndrome and risk of pancreatic cancer: A population‐based prospective cohort study. Issue 12 (29th July 2020) - Xia, Bin
Abstract: Metabolic syndrome (MetS) and its components may link to pancreatic cancer risk; however, current epidemiological evidence is limited, and the potential mechanisms underlying the associations remain unclear. To investigate this, we carried out this prospective cohort study of 474 929 participants without a diagnosis of cancer based on UK Biobank dataset. MetS was defined according to the International Diabetes Federation criteria and pancreatic cancer was identified through linkage to UK cancer registries (median follow‐up time: 6.6 years). We evaluated hazard ratio (HR) and 95% confidence interval (CI) with Cox proportional hazards regression, adjusting for demography and lifestyle factors. Restricted cubic spline was performed for each MetS component to investigate their possible nonlinear associations with risk of pancreatic cancer. During 3 112 566 person‐years of follow‐up, 565 cases of pancreatic cancer were identified. Individuals with MetS (HR = 1.31, 95% CI, 1.09‐1.56), central obesity (HR = 1.24, 95% CI, 1.02‐1.50) and hyperglycemia (HR = 1.60, 95% CI, 1.31‐1.97) had increased risk of pancreatic cancer. Higher waist circumference (WC) and blood glucose were independently associated with pancreatic cancer, with no evidence against nonlinearity. Although elevated CRP (≥1.00 mg/dL) showed a positive association with the risk for pancreatic cancer, the effect was substantially increased only in participants with MetS and CRP ≥1.00 mg/dL. Our study demonstrated a positive association between MetS and increased risk of pancreatic cancer, with two of the MetS components, WC and blood glucose, showing independent associations in linear manner. Our study also suggested a potential joint effect of MetS and CRP in pancreas tumorigenesis. Abstract : What's new? Metabolic syndrome (MetS) and its predominant components, notably central obesity, increased triglycerides, and insulin resistance, are suspected risk factors for pancreatic cancer. Details regarding these potential associations, however, remain largely unknown. Here, based on data from the UK Biobank, the authors identified independent associations between two MetS components—waist circumference and blood glucose—and increased risk of pancreatic cancer. Elevated levels of C‐reactive protein (CRP) were also associated with increased pancreatic cancer risk, with substantial increases in risk observed in patients with MetS and elevated CRP, suggesting a possible joint effect of MetS and CRP in pancreatic tumorigenesis.